Analyses of reported family history of glaucoma: A preliminary investigation

Autor:	Qimei He, Barbara Nemesure, Nancy R. Mendell, Leske Mc
Rok vydání:	1996
Předmět:	medicine.medical_specialty medicine.diagnostic_test Epidemiology business.industry Fundus photography Family aggregation Glaucoma Odds ratio medicine.disease Surgery Ophthalmology Genetic epidemiology Self-disclosure Medicine Family history Sibling business Demography
Zdroj:	Ophthalmic Epidemiology. 3:135-141
ISSN:	1744-5086 0928-6586
DOI:	10.3109/09286589609080119
Popis:	This study investigated the self-reported family history of open-angle glaucoma (OAG) among 4,314 black participants in the Barbados Eye Study (BES), which was based on a random sample of Barbados-born citizens between 40 and 84 years of age. Data collection included Humphrey perimetry, fundus photography, various ophthalmic and other measurements and a comprehensive interview, including family history. Results showed that participants with OAG and previous OAG treatment reported more family history; maternal history was reported twice as often as paternal history. In persons without previous OAG treatment, those with newly diagnosed OAG reported more sibling history (Odds Ratio = 4.5). The Statistical Analysis for Genetic Epidemiology (S.A.G.E.) system was used to test the transmission models for OAG in a subset of 1,048 families (5,806 individuals) with the most complete self-reported family information. The S.A.G.E. results are consistent with the existence of a major dominant allele for OAG. These results should be viewed as promising, but preliminary, since they are based on self-reported data. More definitive information is currently being collected by the Barbados Family Study of Open-angle Glaucoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1a5b6e4da9a42e80e4760ca876f70c25 https://doi.org/10.3109/09286589609080119 Zobrazit plný text záznamu