The Search for Biomarine-derived Compounds with Immunomodulatory Activity
| Autor: | Lola Corzo, Ramón Cacabelos, Iván Carrera, Valter Lombardi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology Cell Disease Immunoglobulin E 03 medical and health sciences Human health 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immune system 030220 oncology & carcinogenesis Genotype Immunology medicine biology.protein After treatment Effective response |
| Zdroj: | Journal of Exploratory Research in Pharmacology. 3:30-41 |
| ISSN: | 2572-5505 |
| DOI: | 10.14218/jerp.2018.00006 |
| Popis: | Many clinical conditions exist in which it is desirable to stimulate or suppress the immune system, and many different drugs are able to do this. It is also well known that nutrition may affect human health and immune responses. Nutritional factors are crucial components of the diet, essential for the normal growth and development of both vertebrate and invertebrate organisms. Many of these components have been shown to play different roles in the immune response, and under different circumstances they can significantly modulate the immune system to create an effective response. The aim of the present review was to show the effect of a biomarine lipofishin (E-JUR-94013) obtained from the species T. trachurus, present on the Galician coast of the Atlantic Ocean, in the improvement of immune system function. In humans, the results obtained under different clinical conditions clearly demonstrated the ability of E-JUR-94013 to improve the host innate and acquired immune responses. In three different clinical studies, 56, 205 and 1,500 patients were included, respectively. All patients were supplemented with 750 mg/day of E-JUR-94013. In the first study, significant increases in IgA (p = 0.033) and IgG, and a reduction in IgE (p = 0.033) were observed. In the second study, a normalization in leukocyte cell counts after treatment was observed (p < 0.05). The main objective of the last study was to correlate inflammatory genotypes with response to E-JUR-94013. The results obtained indicated that high ultrasensitive C-reactive protein was down-regulated. In addition, both IL-6-C573G and IL1β-T3954C genotypes clearly correlated with response to E-JUR-94013 treatment. Taken together, these results suggest that supplementation of diets with E-JUR-94013 can be employed to improve, enhance and regulate certain immune responses and lead to increased resistance to disease. |
| Databáze: | OpenAIRE |
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