Effects of Sonication Processing on the Behavior of the Synthesis Human Serum Albumin-SPIONs Loaded PLGA Nanoparticles

Autor:	Sri Vidawati, Víctor Mosquera, Pablo Taboada, Silvia Barbosa
Rok vydání:	2019
Předmět:	Chemistry Sonication technology industry and agriculture Nanoparticle macromolecular substances Human serum albumin Plga nanoparticles PLGA chemistry.chemical_compound Chemical engineering Drug delivery medicine Pharmacology (medical) Protein stabilization Iron oxide nanoparticles medicine.drug
Zdroj:	Advances in Biological Chemistry. :179-188
ISSN:	2162-2191 2162-2183
DOI:	10.4236/abc.2019.96014
Popis:	This paper reports the most prominent contributions in the field of biodegradable polymeric nanoparticles from poly (lactic-co-glycolic acid) (PLGA) used as a protein/drug delivery. We use a combination of Human Serum Albumin (HSA)-superparamagnetic iron oxide nanoparticles (SPIONs) loaded PLGA nanoparticles. To obtain protein stabilization, the optimization of each step of synthesis nanoparticle is required. One of the most common problems in encapsulating protein to PLGA nanoparticles is the presence of several challenges as a problem of instability. We explained how the effect of the various sonication processing on the synthesis HSA-SPIONs loaded PLGA nanoparticles would be one of the crucial parameters for stability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::19a90d05a80f43691d50b78dd08c6284 https://doi.org/10.4236/abc.2019.96014 Zobrazit plný text záznamu