Development of a DNA-damaging ferrocene amino acid
| Autor: | Craig J. Yennie, Sarah Delaney, Daniel C. Cooper, Jesse B. Morin, J. William Suggs |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Nuclease biology DNA damage Organic Chemistry Synthon Cleavage (embryo) Biochemistry Combinatorial chemistry Acid anhydride Amino acid Inorganic Chemistry chemistry.chemical_compound Ferrocene chemistry Materials Chemistry biology.protein Organic chemistry Moiety Physical and Theoretical Chemistry |
| Zdroj: | Journal of Organometallic Chemistry. 696:3058-3061 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2011.05.018 |
| Popis: | The oxygen-sensitive ferrocenylacetic acid moiety was incorporated in a water-soluble DNA-damaging agent via the synthon 1,1′-ferrocenediacetic acid anhydride. The extent of plasmid nicking was pH-dependent, with complete cleavage at pH 5.5. The nicking was indiscriminate and required O2, implicating reduced oxygen species as the actual damaging agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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