| Autor: |
A G Stewart, SC-A Chen, K Hamilton, T Harris-Brown, T M Korman, M Figtree, L J Worth, J Kok, D Van der Poorten, K Byth, M A Slavin, D L Paterson |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Open Forum Infectious Diseases. |
| ISSN: |
2328-8957 |
| Popis: |
Background Clostridioides difficile infection (CDI) is associated with significant morbidity and mortality in both healthcare and community settings. Burden and characteristics of disease are not well defined in Australia. We aimed to define the predisposing factors, risks for severe disease and mortality determinants of CDI in Eastern Australia over a 1-year period. Methods This is an observational retrospective study of CDI in hospitalised patients ≥18 years of age in six tertiary institutions from 1 January 2016 to 31 December 2016. Patients were identified through laboratory databases and medical records of participating institutions. Clinical, imaging and laboratory data was input into an electronic database hosted at a central site. Diagnosis, severity, setting of onset, and recurrence for CDI were defined. Results A total of 578 patients (578 CDI episodes) were included. Median age was 65 years (range, 18 to 99 years) and 48.2% were male. Hospital-onset of CDI occurred in 64.0%. Recent antimicrobial use (41.9%) and proton pump inhibitor use (35.8%) was common. Significant risk factors for severe CDI were age Conclusion The burden of CDI is large in Australia and continues to complicate healthcare delivery. Patients who experience CDI are vulnerable and require early diagnosis, clinical surveillance, and effective therapy to prevent complications and improve outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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