Microbial reduction of 1-tetralone 2-carboxyesters as a source of new asymmetric synthons

Autor:	Umberto Guzzi, Jean-Alex Laffitte, Didier Buisson, Roberto Cecchi, Robert Azerad
Rok vydání:	1994
Předmět:	1-Tetralone Organic Chemistry Synthon Absolute configuration Optically active Biochemistry Yeast chemistry.chemical_compound chemistry Drug Discovery Chemical reduction Organic chemistry Enantiomer Enantiomeric excess
Zdroj:	Tetrahedron Letters. 35:3091-3094
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)76837-7
Popis:	The reduction of unsubstituted or methoxy-substituted (±)-2-carboxyethyl-1-tetralones by selected microorganisms affords optically active 1-hydroxy-2-carboxyethyl tetralins which can be used as versatile asymmetric synthons, for example in the preparation of biologically active methoxy-substituted 2R-aminotetralins. 1R,2R-(cis)-hydroxyesters of high optical purity are obtained with yeast strains, while the use of filamentous fungi leads to the enantiomeric 1S,2S-(cis)-hydroxyesters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1931cbed6fe829707c8d223ab4b8f2c1 https://doi.org/10.1016/s0040-4039(00)76837-7 Zobrazit plný text záznamu