Traitement du syndrome néphrotique idiopathique corticorésistant
| Autor: | J. Chemli, A. Harbi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Pediatrics business.industry medicine.medical_treatment Glomerulonephritis medicine.disease Pathophysiology Surgery Nephropathy Transplantation Pediatrics Perinatology and Child Health medicine Plasmapheresis business Nephrotic syndrome Kidney transplantation Kidney disease |
| Zdroj: | Archives de Pédiatrie. 16:260-268 |
| ISSN: | 0929-693X |
| DOI: | 10.1016/j.arcped.2008.11.018 |
| Popis: | Idiopathic nephrotic syndrome (INS) is the most frequent glomerular nephropathy in children. The response to corticoids distinguishes steroid-sensitive nephrotic syndrome (SSINS), by far the most frequent (90% of cases), from steroid-resistant nephrotic syndrome (SRINS). The steroid resistance of nephrotic syndrome is defined by the absence of remission after a full dose of oral corticosteroid therapy for 1 month followed by 3 pulses of intravenous methylprednisolone. Actually, INS constitutes a heterogeneous nosologic entity. Currently, within the SRINS, there are 2 forms that vary greatly in their physiopathology and prognostics: immunologic or sporadic forms, which can be improved by immunosuppressive agents and the genetic or familial forms, which do not respond to any immunosuppressive therapy and usually evolve to end-stage renal insufficiency. In these genetic forms, renal transplantation is the only therapeutic alternative. The aim of this article is to review treatment of SRINS and to propose a management strategy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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