Differential Hypothalamic Secretion of Neurocrines in Male Common Marmosets: Parental Experience Effects?
| Autor: | Megan E. Sosa, Michael J. Woller, Yun Chiang, Jason E. Moore, Toni E. Ziegler, Shelley L. Prudom, Patrick Keelty |
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| Rok vydání: | 2012 |
| Předmět: |
endocrine system
medicine.medical_specialty Vasopressin biology Endocrine and Autonomic Systems Offspring Endocrinology Diabetes and Metabolism Marmoset biology.organism_classification Callithrix Prolactin Cellular and Molecular Neuroscience Endocrinology medicine.anatomical_structure Oxytocin Hypothalamus Internal medicine biology.animal Lactation medicine hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Neuroendocrinology. 24:413-421 |
| ISSN: | 0953-8194 |
| DOI: | 10.1111/j.1365-2826.2011.02252.x |
| Popis: | Pregnancy and lactation produce a plethora of hormonal changes in females that promote maternal care of offspring. Males in the biparental marmoset species (Callithrix jacchus) demonstrate high levels of parenting behaviour and express enhanced circulating reproductive hormones. Furthermore, these hormonal changes are influenced by paternal experience. To determine whether the paternally experienced male marmoset has altered neurocrine hypothalamic release, as the maternal females does, we examined the release of several reproductive neurocrines, dopamine (DA), oxytocin (OT), vasopressin (AVP) and prolactin (PRL), in cultured explants of the hypothalamus of paternally experienced male marmosets compared to naive, paternally inexperienced males. DA levels secreted from the isolated hypothalamus were significantly lower in the experienced males, whereas OT and PRL levels were significantly higher than levels found in inexperienced males. PRL levels decreased rapidly in the hypothalamic media, suggesting that PRL production occurs elsewhere. AVP levels did not change. Stimulation of the cultured explants with oestradiol significantly decreased DA levels in the inexperienced males but did not alter the other neurocrines, suggesting a direct effect of oestradiol on DA suppression in the hypothalamus. Although other factors such as age and rearing experience with siblings may play a role in hypothalamic neurocrine levels, these results demonstrate that paternal experience may impact upon the secretion of neurocrines in a male biparental primate. |
| Databáze: | OpenAIRE |
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