New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates
| Autor: | Bi-Yuan Zheng, Xiao-Hui Peng, Jilin Tang, Mei-Rong Ke, Xingshu Li, Bing-De Zheng, Jian-Dong Huang, Yuan-Yuan Zhao |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Materials science
medicine.medical_treatment Photodynamic therapy 02 engineering and technology General Chemistry Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry In vivo Copper phthalocyanine Phthalocyanine medicine Biophysics Molecule Light Up 0210 nano-technology |
| Zdroj: | Chemical Science. 9:2098-2104 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/c7sc05115h |
| Popis: | Phthalocyanine (Pc) molecules exhibit high extinction coefficients in near-infrared region, rendering them well-suited for phototherapies, but most of their applications are limited to the field of photodynamic therapy (PDT). Herein, for the first time, we illustrate that Pc molecules can be endowed with excellent photothermal properties by means of structural regulation rather than formation of aggregates. Three representative Pc derivatives show efficient activities of photothermal therapy (PTT) against human hepatocellular carcinoma cells. Among them, copper phthalocyanine (PcC1) exhibits a high in vivo PTT efficacy against mice bearing S180 tumors. The unique investigation in this article should light up a perspective of Pc's new applications for PTT, which enable to make up the inherent defects of PDT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|