Formation of sulfate and glucoside conjugates of benzo[e]pyrene by Cunninghamella elegans
| Autor: | Thomas M. Heinze, Carl E. Cerniglia, Frederick E. Evans, Jairaj V. Pothuluri |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
chemistry.chemical_classification
Cunninghamella elegans biology Stereochemistry Metabolite Mutagen General Medicine medicine.disease_cause biology.organism_classification Applied Microbiology and Biotechnology chemistry.chemical_compound chemistry Benzopyrene polycyclic compounds medicine Benzo(e)pyrene Pyrene Aromatic hydrocarbon Carcinogen Biotechnology |
| Zdroj: | Applied Microbiology and Biotechnology. 45:677-683 |
| ISSN: | 1432-0614 0175-7598 |
| DOI: | 10.1007/s002530050747 |
| Popis: | Benzo[e]pyrene is a pentacyclic aromatic hydrocarbon, which, unlike its structural isomer benzo[a]pyrene, is not a potent carcinogen or mutagen. The metabolism of benzo[e]pyrene was studied using the filamentous fungus Cunninghamella elegans ATCC 36112. C. elegans metabolized 65% of the [9, 10, 11, 12-3H]benzo[e]pyrene and unlabeled benzo[e]pyrene added to Sabouraud dextrose broth cultures after 120 h of incubation. Three major metabolites of benzo[e]pyrene were separated by reversed-phase high-performance liquid chromatography. These metabolites were identified by 1H and 13C NMR, UV-visible, and mass spectral analyses as 3-benzo[e]pyrenylsulfate, 10-hydroxy-3-benzo[e]pyrenyl sulfate, and benzo[e]pyrene 3-O-β-glucopyranoside. |
| Databáze: | OpenAIRE |
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