| Autor: |
Pablo Regner, Carlos Fabián Damin, Marcela Alejandra Desio, Daniel Dozoretz, Laura Cecilia Lanari, Adolfo Rafael de Roodt, Leandro Calderón, Vanessa Costa de Oliveira, Néstor Lago, Fernando Morón Goñi |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Proceedings of 1st International Electronic Conference on Toxins. |
| Popis: |
Crotalus atrox is one of the species of venomous snakes most commonly found in herpetological collections around the world and it is usually commercialized in the black market. Several collections have specimens but lack of the specific antivenom. We tested the toxicity of venom of adults and young snakes (2 to 3 years old) specimens of C. atrox in captivity and the para-specific neutralization provided by the antivenoms most used in Argentina. The i.p. lethal potency of the venoms were 100(95-105) μg and 43(42-45) μg20g mouse and the indirect hemolytic activity was 7.9 (6.7-9.2) μg and 9.0(8.3-9.9) for adults and juvenile venoms. Despite the adult´s venoms lower lethal potency, these venoms were more difficult to neutralize, around 1.5 ml of antibothropic Antivenom (AB) were necessaries to neutralize 1 mg of venom in contrast to 0.54 ml required to neutralize young´s venoms. The neutralization by the Anticrotalic (AC) antivenom was despicable. The dose of AB required for the neutralization 5.0 LD50 of young snakes was in the range of those required for the neutralization of the specific venoms, nevertheless the dose required to neutralize venom from adults was 6 fold higher. The experiments using 2LD50 as challenge dose, showed similar results. The indirect hemolysis caused by both venoms was similarly neutralized by AB (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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