ChemInform Abstract: The Synthesis of 1′-N-Methyl-2′-oxoanabasine, an Analogue of Cotinine

Autor:	A. J. Hutt, J. W. Gorrod, G. Aislaitner
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Bromine chemistry Geminal Metabolite Microsome chemistry.chemical_element General Medicine Zinc DEPT Cotinine Medicinal chemistry Derivative (chemistry)
Zdroj:	ChemInform. 25
ISSN:	0931-7597
DOI:	10.1002/chin.199431265
Popis:	The synthesis of 1′-N-methyl-2′-oxoanabasine, a hepatic microsomal metabolite of 1′-N-methylanabasine is described. Treatment of 1′-N-methylanabasine with bromine yielded an intermediate geminal dibrominated derivative, the structure of which has been confirmed by DEPT and COSY spectra. Treatment of the intermediate with zinc yielded the required compound.
Databáze:	OpenAIRE
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