Synthesis, biological evaluation and colorimetric sensing studies of platinum group metal complexes comprising pyrazine based thiourea derivatives
| Autor: | Siewdorlang Diamai, Krishna Mohan Poluri, Jaya Lakshmi Tyagi, Werner Kaminsky, Lathewdeipor Shadap, Mohan Rao Kollipara |
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| Rok vydání: | 2019 |
| Předmět: |
Pyrazine
010405 organic chemistry Chemistry Organic Chemistry Cationic polymerization chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Rhodium Adduct Inorganic Chemistry Metal chemistry.chemical_compound Thiourea visual_art Materials Chemistry visual_art.visual_art_medium Chelation Iridium Physical and Theoretical Chemistry |
| Zdroj: | Journal of Organometallic Chemistry. 897:207-216 |
| ISSN: | 0022-328X |
| DOI: | 10.1016/j.jorganchem.2019.07.011 |
| Popis: | A series of complexes ( 1 – 9 ) were synthesized by the reaction of halide bridged metal precursors with the three pyrazine thiourea ligands L1 , L2 and L3 to yield cationic as well as neutral complexes and characterized by various spectroscopic techniques. The cationic complexes are represented by the general formula [(arene)M(L)Cl] + , where L = L1 , L2 and L3 , arene = p -cymene, Cp* and M = Ru, Rh and Ir. All the cationic complexes were isolated with chloride/PF 6 as the counter ion. Reactions of rhodium and iridium dimers with L2 yielded neutral complexes 5 and 6 with the general formula [(arene)M(L)Cl 2 ]. The neutral complexes 5 and 6 were further reacted with NaN 3 to yield azido complexes 10 and 11 . These complexes were, in turn, reacted with acetylene derivatives to yield triazolo complexes 12 – 15 where only a few triazolo complexes of Cp* have been reported. X-ray diffraction studies revealed the complexes having a typical piano stool geometry around the metal center with the thiourea adducts binding to the metal center in a chelating (N, S) manner. Furthermore, the complexes 1 – 9, as well as the ligands were screened for potential anti-bacterial agents out of which complexes 3 and 5 exhibited anti-bacterial activity. Colorimetric sensing studies showed the agglomeration of the silver NPs upon addition of the ligands while the complexes were unresponsive. |
| Databáze: | OpenAIRE |
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