The relevance of hs-troponin and global longitudinal strain in predicting the need for mechanical intubation in severe COVID-19 patients
| Autor: | L F K Wardhani, M Y Alsagaff, I P Dewi, Y H Oktaviono, C P Budianto, H Susilo, B B Dharmadjati, A Subagjo, B S Pikir, N Luthfah, R A Nugraha, T S Putra, R I Gunadi, M J Al-Farabi, Y Azmi |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | European Heart Journal: Acute Cardiovascular Care. 12 |
| ISSN: | 2048-8734 2048-8726 |
| Popis: | Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Dr.Soetomo General Hospital Abbott Background The occurrence of an imbalance in oxygen supply results in the release of pro-inflammatory cytokines which leads to increased ventilation support requirement. Half of the intubated patients with COVID-19 manifest myocardial injury, which is associated with a graded increase in overall mortality. Purpose This study aims to analyze factors that contribute to worse outcomes among severe COVID-19 infections. Methods We performed an observational, single-center prospective cohort study from February 1st – July 31st, 2021 at an Isolated ICU. A total of 65 subjects were included. Subjects were recruited according to WHO criteria for severe COVID-19 and CDC criteria for myocarditis. All subjects recruited were examined using echocardiography to measure global longitudinal strain (GLS) and blood samples were taken to measure hs-Troponin. Subjects were then followed to assess their needs for mechanical ventilation and in-hospital mortality. Results Severe COVID-19 subjects with cardiac injury were associated with an increased need for intubation (78.5%) and an increased incidence of myocarditis (50.8%). There was an association between the use of intubation and the risk of mortality in patients (66.7% vs. 33.3%, p-value Conclusions Severe COVID-19 subjects are associated with an increased incidence of myocarditis as indicated by myocardial injury through an increase in hs-troponin and a decrease in GLS. Both increased hs-troponin and reduced GLS are associated with higher mechanical ventilation needs and a higher mortality rate. |
| Databáze: | OpenAIRE |
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