MR-Signalverhalten des 4 Wochen alten okklusiven Myokardinfarktes im Tierexperiment
| Autor: | Ulrich Vogel, F. S. Eckstein, Claus D. Claussen, Thomas Nägele, Stephan Miller, Ulrich Hahn, Albertus M. Scheule, Fritz Schick |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Pathology Necrosis medicine.diagnostic_test business.industry Granulation tissue Connective tissue Magnetic resonance imaging medicine.disease medicine.anatomical_structure Mole medicine Radiology Nuclear Medicine and imaging Histopathology Myocardial infarction medicine.symptom business Ligation Nuclear medicine |
| Zdroj: | RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren. 172:527-533 |
| ISSN: | 1438-9010 1438-9029 |
| DOI: | 10.1055/s-2000-3764 |
| Popis: | dial Infarctions in Sheep. Purpose: To correlate signal behaviour in T 1 - and T 2 -weighted images after Gd-DTPA with regional histopathology in occlusive myocardial infarction (Ml). Methods: Ligation of a diagonal branch of the LAD was performed in seven sheep. Four weeks later 0.1 mmol Gd-DTPA/kg were injected in five sheep 15 min before cardiac arrest and the sheep were slaughtered. In vitro imaging was performed at 1.5 T included T 1 - and T 2 -weighted spin echo sequences in long and short axis views. Signal intensities (SI) were determined in 36 myocardial segments per slice and compared to macro- and microscopy. Results: In all animals an antero-lateral infarct region was evident histologically. This region presented with increased T 2 SI and T 1 SI after Gd-DTPA. The number of segments with increased SI in T 1 -weighted images was higher (n=195 segments) compared to segments with increased T 2 SI (n=122 segments). Granulation tissue could be differentiated from rarely vascularized connective tissue at a high level of significance (p |
| Databáze: | OpenAIRE |
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