Association of SGLT-2 inhibitors with bacterial urinary tract infection in type 2 diabetes

Autor: Mustafa Tanriverdi, Mehmet Bastemir, Hadiye Demirbakan, Alperen Ünalan, Merve Türkmen, Gülşen Özkan Tanrıverdi
Rok vydání: 2023
DOI: 10.21203/rs.3.rs-2290789/v1
Popis: Objective We aimed to investigate the factors associated with UTI in patients with T2D whether being treated with SGLT-2i or not. Methods Adult patients with T2D, whose urine culture results were available, were analyzed retrospectively. Urine culture was obtained from mid-flow urine. Antibacterial treatment was given to the patients with UTI, which was defined by positive urine cultures and/or clinical findings. Results A total of 101 patients were included. Median age was 56 (45–67), 56.4% (n = 57) of the patients were female. Urine culture was positive in 54.9% (n = 28) and 16% (n = 8) of Group A (n = 51) and Group B (n = 50), respectively. Of those for whom urine culture was positive, E. coli was isolated in 83.3% (n = 30), and both E. coli and Klebsiella pneumonia (K.pneumonia) were isolated in 16.7% (n = 6). K. pneumonia was isolated only from Group A. The need for and duration of hospitalization were higher in Group A (p 5.8% was associated with UTI with good accuracy (AUC: 0.835, p
Databáze: OpenAIRE