| Autor: |
Ali Jawaid, Paul E. Schulz, Adriana M. Strutt, Alicia R. Salamone, Paul J. Massman, D. Mosnik, Stanley H. Appel, Major R. Bradshaw, M. Witgert |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
European Journal of Neurology. 17:103-110 |
| ISSN: |
1351-5101 |
| Popis: |
Background: Cognitive impairment secondary to frontal lobe atrophy exists in 40–60% of Amyotrophic Lateral Sclerosis (ALS) cases. We aimed to determine the prevalence of frontal-lobe mediated behavioral impairment in (ALS) and to ascertain its relationship to cognitive impairment. Methods: Two-hundred and twenty five patients diagnosed with sporadic ALS were evaluated for behavioral dysfunction using the Frontal Systems Behavior Scale (FrSBe), a validated measure used to examine frontal-lobe mediated behaviors, specifically apathy, executive dysfunction and disinhibition; a total behavior score is also provided. Additionally, a subset of patients also underwent a comprehensive neuropsychological evaluation. Results: Changes in the total FrSBe scores were observed in 24.4% of the patients and 39.6% of the patients had impairment in at least one behavioral domain with symptoms of Apathy being the most common (31.1%). Cognitively impaired ALS patients had worse total (P = 0.05) and apathy scores (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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