Antiinflammatory effects of 5‐HT3receptor antagonists in lipopolysaccharide‐stimulated primary human monocytes
| Autor: | Ravi Shankar Akundi, T Stratz, D Gmeiner, Eduardo Candelario-Jalil, Wolfgang Müller, K Lieb, Bernd L. Fiebich, Eduardo Muñoz, U Haus |
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| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Scandinavian Journal of Rheumatology. 33:28-32 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.1080/03009740410006998 |
| Popis: | There is evidence from both human and animal research that 5‐hydroxytryptamine (5‐HT)3 receptor antagonists, particularly tropisetron, exert analgesic and antiinflammatory effects. However, the underlying mechanisms of these effects have not yet been investigated in detail. Therefore, the antiinflammatory effects of tropisetron and ondansetron were investigated in human monocytes. In human monocytes, both lipopolysaccharide (LPS)‐stimulated tumour necrosis factor (TNF)‐α and interleukin (IL)‐1β secretion were dose‐dependently inhibited by tropisetron starting at a concentration of 5 μg/mL and reaching maximal levels at 25 μg/mL (IC50: 32 μg/mL and 12 μg/mL, respectively). LPS‐induced IL‐6 and PGE2 release was only slightly inhibited at high doses, whereas LPS‐induced release of IL‐8 and matrix metalloprotease (MMP)‐9 was not affected. In conclusion, our data show that the binding of tropisetron to 5‐HT3 receptors results in antiinflammatory effects through inhibition of TNF‐α/IL‐1β, which might explain th... |
| Databáze: | OpenAIRE |
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