ChemInform Abstract: Rhodium-Catalyzed Asymmetric Hydrosilylation of Ketones Employing a New Ligand Embodying the Bis(oxazolinyl)pyridine Moiety

Autor:	Asit R. Sarkar, Govindaswamy Manickam, Atanu Ghoshal, R. Senthil Kumaran, Jayadevan Jayashankaran
Rok vydání:	2010
Předmět:	Hydrosilylation Ligand chemistry.chemical_element General Medicine Medicinal chemistry Pyridine moiety Rhodium Catalysis chemistry.chemical_compound Suzuki reaction chemistry Pyridine Electronic effect Organic chemistry
Zdroj:	ChemInform. 41
ISSN:	0931-7597
DOI:	10.1002/chin.201043066
Popis:	A general approach to new ligands embodying bis(oxazolinyl)pyridine has been developed, employing palladium-catalyzed Suzuki coupling and base-mediated cyclization as pivotal steps. A rhodium catalyst derived from the ligand 4-(4-ethylphenyl)-2,6-bis(4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine gave excellent enantioselectivity in the asymmetric hydrosilylation of ketones. In addition the electronic effect of remote substituents on the catalytic activity of rhodium catalyst was studied.
Databáze:	OpenAIRE
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