Revisiting the Conformation and Dynamics of DNA in Slitlike Confinement

Autor:	Jing Tang, Harold G. Craighead, S.L. Levy, Jeremy J. Jones, Patrick S. Doyle, Daniel W. Trahan
Rok vydání:	2010
Předmět:	Inorganic Chemistry Nuclear magnetic resonance Polymers and Plastics Chemistry Organic Chemistry Dynamics (mechanics) Materials Chemistry Radius of gyration Molecule Thermal diffusivity Confined space Slit Molecular physics
Zdroj:	Macromolecules. 43:7368-7377
ISSN:	1520-5835 0024-9297
DOI:	10.1021/ma101157x
Popis:	We experimentally investigated the equilibrium conformation and dynamics of single DNA molecules in slitlike nanochannels. We measured the in-plane radius of gyration (R ) diffusivity (D), and longest relaxation time (τ)ofλ-DNA (48.5 kbp) as functions of the slit height using fluorescence microscopy. Our results show that the in-plane radius of gyration increases monotonically with decreasing slit height, in contrast to results from Bonthuis et al. 15 but in agreement with our simulations and those of other groups. In strongconfinement (slit height
Databáze:	OpenAIRE
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