Can a single measurement of carbamazepine suffice for therapeutic monitoring?

Autor:	M I Arranz Peña, E. Saenz Lope
Rok vydání:	1987
Předmět:	Saliva Chromatography business.industry medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Single measurement Single sample Carbamazepine Pharmacology Therapeutic monitoring Anticonvulsant Morning dose Fluorescence polarization immunoassay Medicine business medicine.drug
Zdroj:	Clinical Chemistry. 33:812-813
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/33.6.812
Popis:	Using fluorescence polarization immunoassay, we measured the peak and trough concentrations of total and free carbamazepine in serum and saliva from 33 epileptic children. We found that, except for patients who show side effects, measurement of trough values in a single sample, collected after an overnight fast and before the morning dose, sufficiently estimates clinical response. Moreover, total carbamazepine is as informative as free carbamazepine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::15778cf78a66e09c53906164e8f36b22 https://doi.org/10.1093/clinchem/33.6.812 Zobrazit plný text záznamu