Comparison of Pakistani and Chinese Ephedra Herba-Containing Gangjihwan in the Improvement Effects of Nonalcoholic Fatty Liver Disease in a High Fat Diet-Fed NAFLD Mouse Model
| Autor: | Ye Ji Ahn, Jong Hoon Kim, Yang Sam Jung, Michung Yoon, Won Kyung Lee, Jae Sang Yoo, Ja Ryong Ku, Ju Heum Jo, Du Hyon Jang, Hoa Jun Seok, Ki Hyeon Yoon, Soon Shik Shin, Jong Seong Roh, Byeong Chul Kim |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Cholesterol business.industry Atorvastatin Blood lipids Histology medicine.disease Liver weight chemistry.chemical_compound Endocrinology Fat diet chemistry Internal medicine Nonalcoholic fatty liver disease medicine Standard diet lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | Herbal Formula Science. 22:113-122 |
| ISSN: | 1229-1218 |
| DOI: | 10.14374/hfs.2014.22.1.113 |
| Popis: | Objectives : This study investigated the improvement effects of Pakistani (DF-a) and Chinese Ephedra herba-containing Gangjihwan (DF-b) on nonalcoholic fatty liver disease in a high fat diet-induced obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into five groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and atorvastatin, DF-a, and DF-b groups given a high fat diet with atorvastatin (10 mg/kg), DF-a (80 mg/kg), and DF-b (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, blood lipid markers, ALT concentrations, liver weight and histology were examined. Results : 1. Body weight gain was significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control. The extent of decreases was eminent in DF-a group.2. Circulating concentrations of total cholesterol and LDL-cholesterol were significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control. The decreases were most effective in atorvastatin group.3. Liver weights were decreased in DF-a, DF-b, and atorvastatin groups compared with control. In particular, liver weight was significantly reduced in DF-b group.4. Hepatic lipid accumulation was significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control, and the magnitude of which was most effective in DF-b group.5. Circulating ALT concentrations were decreased in DF-a, DF-b, and atorvastatin groups compared with control, but ALS levels were significantly reduced only in DF-b group. |
| Databáze: | OpenAIRE |
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