Mechanisms of Immunomodulatory and Membranotropic Activity of Trehalolipid Biosurfactants (a Review)

Autor:	Maria S. Kuyukina, I. B. Ivshina, O. A. Kochina, Valery A. Chereshnev, S. V. Gein
Rok vydání:	2020
Předmět:	0106 biological sciences 0301 basic medicine chemistry.chemical_classification Reactive oxygen species medicine.medical_treatment Immunotherapy 01 natural sciences Applied Microbiology and Biotechnology Biochemistry Trehalose 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Glycolipid Cytokine Immune system chemistry 010608 biotechnology medicine bacteria Receptor Lipid bilayer
Zdroj:	Applied Biochemistry and Microbiology. 56:245-255
ISSN:	1608-3024 0003-6838
DOI:	10.1134/s0003683820030072
Popis:	Of the glycolipid biosurfactants with possible medical applications, trehalolipids produced by the actinobacteria in the Rhodococcus genus are intensively studied due to their lower toxicity as compared to mycobacterial trehalose di- and monomycolates. The immunomodulatory activity of trehalolipids is based on their interaction with surface receptors on the membrane of immune cells, which trigger the signal system. This leads to the activation of cytokine, reactive oxygen species, and antibody production. Being amphiphilic, trehalose lipids can interact with the lipid bilayer and change its permeability. The discussed molecular mechanisms of the interaction between trehalolipids and immune system cells are important for the development of new immunotherapy approaches.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::155f45feb5ab2c8c156f02f272e8cacb https://doi.org/10.1134/s0003683820030072 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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