Fetal sheep central haemodynamics and cardiac function during occlusion of the ascending aorta
| Autor: | Juulia Junno, Pasi Ohtonen, A. Roger Hohimer, Heikki Huhta, Juha Rasanen, Tiina Erkinaro, Mervi Haapsamo, Lowell E. Davis, Ganesh Acharya |
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| Rok vydání: | 2017 |
| Předmět: |
Cardiac function curve
Aortic arch medicine.medical_specialty Cardiac output 030219 obstetrics & reproductive medicine business.industry Diastole Hemodynamics General Medicine 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Internal medicine medicine.artery Ductus arteriosus Ascending aorta Occlusion cardiovascular system medicine Cardiology business |
| Zdroj: | Experimental Physiology. 103:58-67 |
| ISSN: | 0958-0670 |
| DOI: | 10.1113/ep086500 |
| Popis: | Fetal aortic isthmus (AoI) allows communication between left (LV) and right (RV) ventricular outputs and represents arterial watershed between the brachiocephalic (brain) and subdiaphragmatic (placenta) circulations. To understand the capability of AoI to maintain the balance between upper and lower body circulations, we performed a complete fetal ascending aorta occlusion in 9 chronically instrumented sheep at near term gestation. We hypothesized that the occlusion would significantly decrease LV output and concomitantly increase RV output in order to maintain adequate systemic cardiac output and perfusion pressure to the fetal brain circulation through retrograde filling of the AoI. Fetal cardiac function and hemodynamics were assessed by pulsed and tissue Doppler at baseline, 15 and 60 minutes after ascending aorta occlusion, and 15 minutes after occlusion was released. Carotid artery and jugular vein pressures were monitored. Ascending aorta occlusion increased (P |
| Databáze: | OpenAIRE |
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