Comparison of the bioavailability of cyanocobalamin from capsule and liquid dosage forms

Autor:	B. M. Bowen, D C Baun, D E Wood
Rok vydání:	1975
Předmět:	Pharmacology Absorption (pharmacology) Excretion Chromatography Chemistry Health Policy Capsule Cyanocobalamin Solubility Dosage form Intestinal absorption Bioavailability
Zdroj:	American Journal of Health-System Pharmacy. 32:1047-1051
ISSN:	1535-2900 1079-2082
DOI:	10.1093/ajhp/32.10.1047
Popis:	Comparative in vivo absorption of cyanocobalamin from two dosage forms, gelatin capsule and liquid, was studied. Forty-two subjects received simultaneous doses of cyanocobalamin in capsule and liquid form, labeled with cobalt-57 and cobalt-60, respectively. Excretion, a measure of absorption, was between 2 percent and 66 percent greater with the liquid form. In vitro dissolution studies showed that the capsules had a tendency to collapse into a stringy mass and to dissolve slowly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::14f1a2c24a225d0323c78419536e6941 https://doi.org/10.1093/ajhp/32.10.1047 Zobrazit plný text záznamu