The beneficial effect of a phytonutrient-rich product against cadmium chloride-induced hepatorenal toxicity
| Autor: | Omotayo Babatunde Ilesanmi, Ridwan Abiodun Lawal |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Ukrainian Journal of Nephrology and Dialysis. :26-35 |
| ISSN: | 2616-7352 2304-0238 |
| DOI: | 10.31450/ukrjnd.4(72).2021.04 |
| Popis: | This study was designed to investigate the hepatorenal protective effects of trévo, on cadmium-induced renal and hepatic injury in male Wistar rats. Methods. Fifteen healthy male Wistar rats were divided into three groups of five rats per group. Group I (control); group II (35mg/kg cadmium chloride (CdCl2); Group III (2 ml/kg trévo+ CdCl2. The rats were treated with trévo (2ml/kg orally) and administered CdCl2 3 hrs later. Twenty-four hours after the last administration rats were sacrificed and blood was collected via cardiac puncture and processed for hematological parameters and assessment of urea, creatinine (CREA), and uric acid (UA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and albumin (ALB). The liver and kidney were excised and processed for markers of oxidative stress. Results intraperitoneal administration of 35 mg/kg of CdCl2 caused a significant increase in serum concentration of urea, CREA, UA, AST, ALT, while the concentration of ALB was significantly lower (P |
| Databáze: | OpenAIRE |
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