Fast production of highly concentrated reactive [18F] fluoride for aliphatic and aromatic nucleophilic radiolabelling

Autor:	Samuel Voccia, David Goblet, Alain Plenevaux, Fabrice Giacomelli, David Thonon, Joël Aerts, André Luxen, Christian Lemaire, Geoffrey Warnock
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Nucleophile Yield (chemistry) Labelling Organic Chemistry Drug Discovery Organic chemistry Ammonium 18f fluoride Biochemistry Alkyl
Zdroj:	Tetrahedron Letters. 51:64-66
ISSN:	0040-4039
Popis:	The use of a polymeric solid support loaded with a long alkyl chain quaternary ammonium allows the rapid and efficient recovery of cyclotron produced [18F]F− from [18O]water to a low water content organic solution compatible with fast nucleophilic labelling of most precursors for PET radiopharmaceuticals in high yield.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::149720b0bc02025ffbe5a5c6f5696312 https://doi.org/10.1016/j.tetlet.2009.10.085 Zobrazit plný text záznamu Full Text from ScienceDirect