Haemolytic uraemic syndrome following bone marrow transplantation. Case report and review of the literature
| Autor: | Cornelis A. Verburgh, S. Van Veen, C. G. Vermeij, J. M. J. M. Zijlmans, L. A. Van Es |
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| Rok vydání: | 1996 |
| Předmět: |
Hemolytic anemia
Transplantation medicine.medical_specialty Thrombotic microangiopathy business.industry medicine.medical_treatment Total body irradiation medicine.disease Gastroenterology Surgery Sepsis surgical procedures operative medicine.anatomical_structure immune system diseases Nephrology hemic and lymphatic diseases Cyclosporin a Internal medicine medicine Hemodialysis Bone marrow Complication business |
| Zdroj: | Nephrology Dialysis Transplantation. 11:1332-1337 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/11.7.1332 |
| Popis: | Thrombotic microangiopathy (TMA) can be a late complication of bone marrow transplantation (BMT). A patient is described in whom the haemolytic uraemic syndrome developed 10 months after BMT and who died of E. coli sepsis while on maintenance haemodialysis. The literature is reviewed, regarding clinical presentation, incidence, pathogenesis and therapy. TMA can be observed, after an interval of 3-12 months, in about 6-26% of patients following BMT. Reported cases vary considerably in clinical severity, from mild presentations to severe TMA with high mortality rates despite intensive therapy. Important pathogenetic roles are ascribed to the conditioning total body irradiation and the use of cyclosporin A, but other factors may be involved as well. Next to supportive therapy, plasma exchange and the use of ACE inhibitors may be of value in treating BMT-associated TMA. |
| Databáze: | OpenAIRE |
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