Effective Lipid Modification by Partial Ileal Bypass Reduced Long-term Coronary Heart Disease Mortality and Morbidity: Five-Year Posttrial Follow-up Report From the POSCH
| Autor: | Stanley E. Williams, Betty J. Hansen, Gilbert S. Campbell, Albert E. Yellin, Robert D. Smink, W. Allan Edmiston, James R. Boen, Christian T. Campos, Henry Buchwald, Henry S. Sawin, Malcolm B. Pearce, Richard L. Varco |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Ejection fraction business.industry medicine.medical_treatment Jejunoileal bypass medicine.disease Surgery Coronary artery disease Coronary artery bypass surgery Internal medicine Statistical significance Internal Medicine medicine Cardiology Myocardial infarction Lipid modification Risk factor business |
| Zdroj: | Archives of Internal Medicine. 158:1253 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.158.11.1253 |
| Popis: | Background In 1990, when the Program on the Surgical Control of the Hyperlipidemias (POSCH) reported its in-trial results strongly supporting the conclusion that effective lipid modification reduces progression of atherosclerosis, the differences for the end points of overall mortality and mortality from atherosclerotic coronary heart disease (ACHD) did not reach statistical significance. Methods The Program on the Surgical Control of the Hyperlipidemias recruited men and women with a single documented myocardial infarction between the ages of 30 and 64 years who had a plasma cholesterol level higher than 5.69 mmol/L (220 mg/dL) or higher than 5.17 mmol/L (200 mg/dL) if the low-density lipoprotein cholesterol level was in excess of 3.62 mmol/L (140 mg/dL). Between 1975 and 1983, 838 patients were randomized: 417 to the diet control group and 421 to the diet plus partial ileal bypass intervention group. Mean patient follow-up for this 5-year posttrial report was 14.7 years (range, 12.2-20 years). Results At 5 years after the trial, statistical significance was obtained for differences in overall mortality ( P =.049) and mortality from ACHD ( P =.03). Other POSCH end points included overall mortality (left ventricular ejection fraction ≥50%) ( P =.01), mortality from ACHD (left ventricular ejection fraction ≥50%) ( P =.05), mortality from ACHD and confirmed nonfatal myocardial infarction ( P P P P P =.02). There were no statistically significant differences between groups for cerebrovascular events, mortality from non-ACHD, and cancer. All POSCH patients have been available for follow-up. Conclusion At 5 years after the trial, all POSCH mortality and atherosclerosis end points, including overall mortality and mortality from ACHD, demonstrated statistically significant differences between the study groups. |
| Databáze: | OpenAIRE |
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