MicroRNA-21 is a critical regulator of the antiviral NK cell response
| Autor: | Clair Geary, Colleen Lau, Carolyn Zawislak, Endi K Santosa, Melissa Berrien-Elliott, Natalie Bezman, Lewis L Lanier, Todd A Fehniger, Joseph Chai-Yuen Sun |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 202:76.9-76.9 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.202.supp.76.9 |
| Popis: | Natural killer (NK) cells are innate lymphocytes that possess adaptive features, including antigen-specific clonal expansion and memory responses. Global loss of microRNAs (miRNAs) leads to defects in NK cell homeostasis and antiviral responses; however, the role of individual miRNAs in these processes is poorly defined. Here, we investigated miR-21, a highly expressed miRNA in both human and mouse NK cells. While miR-21 was largely dispensable for NK cell development, miR-21-deficient NK cells failed to mediate significant host protection against mouse cytomegalovirus (MCMV) due to defective proliferation. Although activated NK cells upregulated miR-21 early after MCMV exposure, loss of miR-21 did not impact NK cell activation or effector molecule expression during viral infection. Transcriptome analysis of miR-21-deficient NK cells demonstrated dysregulation of cell cycle regulators, including several predicted targets of miR-21. Altogether, our findings demonstrate a novel role for miR-21 as a crucial regulator of adaptive NK cell responses during MCMV infection. |
| Databáze: | OpenAIRE |
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