| Popis: |
HIV/AIDS has been major source of concern all over the world for past few decades. The current treatment regimes include the use of antiviral drugs belonging to the classes of nucleoside analogue reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs). The use of highly active antiretroviral therapy (HAART) using multiple drugs has raised the life expectancy of HIV-infected patients. However, the HIV infections is yet to be targeted in anatomical reservoirs, such as the brain, testes, gut, liver, kidney, and secondary lymphoid tissue. Potential nanocarriers have been studied and analysed thoroughly to overcome the hurdles in the delivery of antiretroviral drugs for HIV prevention and therapy. This review provides an insight into the life cycle and infection of HIV and various nanoparticulate delivery vehicles used for antiretroviral drugs. Biocompatible polymeric nanoparticles, liposomes and hybrid nanosystems have been thoroughly discussed. Such nanostructured materials hold great promise for the future of HIV treatment and can be expected to improve the quality of life of HIV victims. |
