Microsatellite instability detection in hereditary colorectal cancer: is it possible in a public hospital?

Autor:	O.A. Santapá, Mario Edmundo Barugel, S. Valente, S. Filippini, G. Jankilevich, Enrique Roca, A.M. Di Lonardo
Rok vydání:	2004
Předmět:	Genetics Colorectal cancer Cancer Microsatellite instability General Medicine Biology medicine.disease digestive system diseases Lynch syndrome Cellular dna Cancer cell medicine Microsatellite Allele
Zdroj:	International Congress Series. 1261:505-507
ISSN:	0531-5131
DOI:	10.1016/s0531-5131(03)01702-3
Popis:	Microsatellite analysis is emerging as an important tool in the study of cancer. The addition of novel microsatellite alleles is referred as microsatellite instability (MSI) indicating possible mutations in cellular DNA repair mechanism. The detection of these genetic changes demonstrates the presence of a clonal population of cells that share altered genetic information, which is characteristic of cancer cells. In this study, we analyzed the five MSI markers: D2S123, D5S346, D17S250, BAT 25, BAT 26 recommended at the 1997 National Cancer Institute in a patient with suspicious familiar history of Non-Polyposic Hereditary Colorectal Cancer (NHPCC), Lynch syndrome, and high instability MSI-H was confirmed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13151a7c5c11c2d13a69bb741f5598ea https://doi.org/10.1016/s0531-5131(03)01702-3 Zobrazit plný text záznamu Full Text from ScienceDirect