Effect of Ginkgo biloba extract on sperm quality, serum testosterone concentration and histometric analysis of testes from adult Wistar rats
| Autor: | Cl audia Cristina Teixeira Ribeiro, Leandro Vespoli Campos, S ergio Luis Pinto da Matta, Vera Maria Peters, Martha de Oliveira Guerra, Leonardo Toshio Oshio, Renato Macedo Marques, João Evangelista de Paula Reis, Rita de C assia da Silveira e S a |
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| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
Serum testosterone medicine.medical_specialty biology business.industry Ginkgo biloba Pharmaceutical Science Plant Science medicine.disease biology.organism_classification Sperm law.invention Endocrinology Erectile dysfunction Complementary and alternative medicine law Internal medicine Drug Discovery Toxicity medicine Aphrodisiac Sperm quality business Phytotherapy |
| Zdroj: | Journal of Medicinal Plants Research. 9:122-131 |
| ISSN: | 1996-0875 |
| DOI: | 10.5897/jmpr2015.5730 |
| Popis: | Ginkgo biloba extract is a widely consumed phytotherapic used mainly in the treatment of dementia and Alzheimer’s disease, and it has also been employed to treat erectile dysfunction and as an aphrodisiac. This work was aimed at evaluating its effect on sperm quality, serum testosterone concentration and on the histometric analysis of the testes from adult male Wistar rats. Three-month-old Wistar rats were treated with distilled water (control group) and the aqueous extract of Ginkgo biloba at the dose levels of 3.5 (GBE 3.5); 7.0 (GBE 7.0) and 14.0 mg/kg (GBE 14.0), once daily, for 56 consecutive days. Counting and morphological evaluation of sperm collected from cauda epidydimis were analyzed. Histometric measures of the testes were also taken. This work shows that adult Wistar rats exposed to Ginkgo biloba presented histometric alteration in the volume of the Leydig cells and this finding suggests a possible functional deficit in these cells. Key words: Ginkgo biloba, phytotherapy, rats, sperm, testes, toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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