Studies on lytic enzymes toward cariogenic streptococci. Part VIII. Preparation of disaccharide peptides with immunostimulation from microbial cell walls
| Autor: | Eiji Takahashi, Kanae Yokogawa, Yoshiyuki Takase, Masachika Tsujimoto, Shozo Kotani, Tadashi Takemura, Shigeo Kawata |
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| Rok vydání: | 1984 |
| Předmět: |
chemistry.chemical_classification
biology Stereochemistry Disaccharide Peptide Biological activity biology.organism_classification General Biochemistry Genetics and Molecular Biology Glycopeptide Hydrolysate Cell wall chemistry.chemical_compound Enzyme chemistry Biochemistry General Agricultural and Biological Sciences Lactobacillus plantarum |
| Zdroj: | Agricultural and Biological Chemistry. 48:1783-1793 |
| ISSN: | 1881-1280 0002-1369 |
| DOI: | 10.1271/bbb1961.48.1783 |
| Popis: | Four kinds of disaccharide peptides were isolated from a hydrolysate of L. plantarum cell walls by combined catalysis by M-1 N-acetylmuramidase and AM3-endopeptidase, which were derived from the cultural broth of Stm. globisporus 1829. The chemical structures of these compounds were determined by enzymatic and chemical analyses to be β-N-acetylglucosaminyl-(1→)-N-acetyl-muramyl-l-alanyl-d-isoglutaminyl-(l)-meso-2,6-diaminopimelic acid-(d)-amide (GMP3-A), β-N-acetylglucosaminyl-(1→4)-N-acetylmuramyl-l-alanyl-d-isoglutaminyl-(l)-meso-2,6-diamino-pimelic acid-(d)-amide-(l)-d-alanine (GMP4-A), β-N-acetylglucosaminyl-(1→4)-N,6-O-diacetyl muramyl-l-alanyl-d-isoglutaminyl-(l)-meso-2,6-diaminopimelic acid-(d)-amide (GMP3-B) and β-N-acetylglucosaminyl-(1→4)-N,6-O-diacetylmuramyl-l-alanyl-d-isoglutaminyl-(l)-meso-2,6-diaminopimelic acid-(d)-amide-(l)-d-alanine (GMP4-B). GMP3-A and GMP4-A were obtained in 20 and 10% yields from alkali-treated cell walls of L. plantarum, respectively. These compounds were examined as... |
| Databáze: | OpenAIRE |
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