Investigating nasal cytology as a potential tool for diagnosing occupational rhinitis in woodworkers

Autor:	Luciano Giacomelli, Mariella Carrieri, Giovanni Battista Bartolucci, Federica Aielli, Maria Luisa Scapellato, Claudia Staffieri, Andrea Lovato, Martina Bortoletto, Paolo Boscolo-Rizzo, Gino Marioni, Maria Cristina Da Mosto, Salvatore Romeo
Rok vydání:	2015
Předmět:	medicine.medical_specialty business.industry Mucous membrane of nose Dermatology Infectious Rhinitis Otorhinolaryngology Nasal cytology Immunology otorhinolaryngologic diseases medicine Clinical endpoint Screening method Immunology and Allergy Dust exposure business Trend estimation Nasal symptoms
Zdroj:	International Forum of Allergy & Rhinology. 5:814-819
ISSN:	2042-6976
DOI:	10.1002/alr.21562
Popis:	Background Our primary endpoint was to use nasal cytology to compare woodworkers with unexposed subjects to see if wood dust exposure correlates with specific patterns of inflammatory or infectious rhinitis. A secondary endpoint was to identify any differences in the exposed group's nasal symptoms or nasal cytology by years of exposure or personal exposure levels. Methods Ninety-two woodworkers and 90 controls were assessed using a questionnaire and nasal cytology (on nasal mucosa obtained by scraping). Wood dust exposure was investigated using personal sampling methods. Results Woodworkers reported significantly more nasal symptoms than controls (p < 0.00001). The woodworkers' nasal smears revealed more neutrophils (p = 0.001) and significantly higher mean neutrophil scores (p = 0.001) than control smears. Lymphocytes were also found more often in the woodworkers' rhinocytograms (statistical trend, p = 0.06). Neutrophilic rhinitis was diagnosed more frequently in the exposed workers than in controls (chi-square = 5.97, p < 0.05). Woodworkers with lymphocytes in their nasal smears had been exposed to wood dust for longer periods of time (statistical trend; p = 0.06). No differences in nasal symptoms or cell counts emerged when woodworkers were stratified by levels of personal exposure. Conclusion Nasal cytology should be further investigated in woodworkers before considering it a screening method for identifying woodworkers with chronic inflammatory rhinitis.
Databáze:	OpenAIRE
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