Presence of Felis domesticus Allergen I in the Cat’s Salivary and Lacrimal Glands
| Autor: | R. C. Aalberse, T. M. Vroom, F.J. van Milligen |
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| Rok vydání: | 1990 |
| Předmět: | |
| Zdroj: | International Archives of Allergy and Immunology. 92:375-378 |
| ISSN: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000235168 |
| Popis: | Most of the IgE response in persons allergic to cats is directed against the cat allergen Fe1 d I (Felis domesticus allergen I). Although the presence of Fe1 d I in saliva has been demonstrated, the source of Fe1 d I is not completely known. We measured Fe1 d I concentrations in the cat’s lacrimal and salivary glands and in the excretes lacrimal fluid, milk and saliva. The concentration of Fe1 d I, determined by a radioimmunoassay, in the lacrimal gland was 390–780 mU/g tissue and in the sublingual gland 610 mU/g tissue. In the parotid gland and especially the submandibular gland only low concentrations were found, respectively 70–210 and 40–50 mU/g tissue. In lacrimal fluid 6.8–14 U/ml Fe1 d l was detected, which is comparable to saliva, 4.2–7.0 U/ml, whereas in cat’s milk only 0.33 U/ml Fel d I was found. Immunohistochemical studies with monoclonal antibody directed against Fe1 d I (anti-Fe1 d I) showed the presence of Fe1 d I in the serous cells of the lacrimal gland. Thus, our results demonstrate that in particular the lacrimal gland might be a useful Fe1 d I source. |
| Databáze: | OpenAIRE |
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