Expedient synthesis of lactone analogues of formestane as new potential aromatase inhibitors

Autor:	José A. Paixão, Elisiário J. Tavares da Silva, Maria Luisa Sá e Melo, Maria-José M. Almeida, L. C. R. Andrade, M. M. R. R. Costa, André S. Campos Neves
Rok vydání:	1997
Předmět:	chemistry.chemical_classification biology Chemistry Stereochemistry Formestane chemistry.chemical_compound biology.protein Swern oxidation medicine Androstane Aromatase Isomerization Lactone medicine.drug
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :3487-3490
ISSN:	1364-5463 0300-922X
DOI:	10.1039/a705601j
Popis:	A convenient synthetic strategy for the preparation of ring-D lactones of the androstane derivatives 4, 5 and 6 has been achieved through a high yielding, three-step sequence. Baeyer–Villiger oxidation of 3α,4β-dihydroxy-5α-androstan-17-one 3, previously prepared from a 3-olefin, followed by a TFAA mediated Swern oxidation and subsequent isomerization allowed the preparation of the ring-D lactone analogue of formestane 6.
Databáze:	OpenAIRE
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