The Role of Receptor Transactivation in the Cardioprotective Effects of Preconditioning and Postconditioning

Autor: John P. Headrick, A. V. Krylatov, Raphael Mechoulam, Yi Zhang, N. V. Naryzhnaya, A. Yu. Lishmanov, Leonid N. Maslov, E. I. Barzakh
Rok vydání: 2013
Předmět:
Zdroj: Neuroscience and Behavioral Physiology. 43:1015-1022
ISSN: 1573-899X
0097-0549
DOI: 10.1007/s11055-013-9844-7
Popis: Analysis of published data indicates that activation of adenosine, opioid, bradykinin, calcitonin gene-related peptide (CGRP), and epidermal growth factor (EGF) receptors plays an important trigger role in ischemic preconditioning. Cannabinoids imitate the infarct-limiting effect of preconditioning. Endogenous adenosine, opioids, bradykinin, and CGRP are involved in the infarct-limiting effects of ischemic postconditioning. Cannabinoids also imitate the cardioprotective effect of postconditioning. Recent studies have supported the occurrence of heterodimerization of G-protein-coupled receptors (GPC receptors) and transactivation of EGF receptors by GPC receptors. Intracellular interaction of δ1 opioid receptors and adenosine A1 receptors is important for cardioprotection. Furthermore, evidence has been obtained for the involvement of transactivation of EGF receptors by a multitude of GPC receptors, including adenosine, acetylcholine, bradykinin, and opioid receptors. These data support the occurrence of convergent pathways in which multiple GPC receptors can interact (or function independently) and transactivate EGF receptor-dependent kinase signaling to provide cytoprotection.
Databáze: OpenAIRE
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