Comparison Between Esophagectomy and Definitive Chemoradiotherapy in Patients With Esophageal Cancer
| Autor: | Heng Chung Chen, Wei Heng Hung, Hui Shan Chen, Bing Yen Wang, Ching Hsiung Lin, Shiao Chi Wu, Chang Lun Huang |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry medicine.medical_treatment Retrospective cohort study 030204 cardiovascular system & hematology Esophageal cancer medicine.disease Gastroenterology Cancer registry 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Esophagectomy Internal medicine Propensity score matching medicine Surgery Stage (cooking) Cardiology and Cardiovascular Medicine business Survival analysis Cohort study |
| Zdroj: | The Annals of Thoracic Surgery. 107:1060-1067 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/j.athoracsur.2018.11.036 |
| Popis: | Background This study compared survival between definitive chemoradiotherapy (CRT) and esophagectomy alone among patients with locoregional esophageal squamous cell carcinoma (SCC). Methods Data were obtained from the Taiwan Cancer Registry between 2008 and 2014. Included were 5,487 patients with clinical I, II, or III esophageal SCC who received definitive CRT or esophagectomy alone. Patients were stratified according to clinical stage. Overall survival was compared between patients treated with definitive CRT versus esophagectomy alone, and between patients in the three different clinical stages. Propensity-matched analysis along with univariate and multivariate analysis were performed. Results Treatment was with definitive CRT in 4,251 patients (77.50%) and esophagectomy alone in 1,236 (22.50%). Propensity score matching produced 1,020 patients for comparison. The overall survival rates at 1, 2, and 3 years were 60.92%, 34.96%, and 26.14%, respectively, for propensity-matched patients treated with definitive CRT and were 71.15%, 56.50%, and 46.17%, respectively, for propensity-matched patients treated with esophagectomy alone (p Conclusions Esophagectomy alone could provide better survival than definitive CRT for patients with clinical stage I/II esophageal SCC. However, definitive CRT and esophagectomy yield similar overall survival rates in clinical stage III patients. |
| Databáze: | OpenAIRE |
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