ChemInform Abstract: A New Convenient Synthesis of 1-(3-Hydroxy-4-methoxyphenyl)ethane-1,2-diol (iso-MHPG) and Its Enantiomers

Autor:	Adrian J. Fisher, Frank Kerrigan
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Dihydroxylation Diol Enantioselective synthesis Organic chemistry General Medicine Enantiomer
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199849109
Popis:	A safe and efficient process has been developed for the multigram synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (iso-MHPG) 2, via osmium-catalysed dihydroxylation of 3-benzyloxy-4-methoxystyrene 5, and subsequent debenzylation. The methodology has been extended to an asymmetric synthesis of both enantiomers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::10c89c7a0d491c3fd8ab83bdbde3b3fb https://doi.org/10.1002/chin.199849109 Zobrazit plný text záznamu Plný text