Learning Curve and One-Year Outcome of XEN 45 Gel Stent Implantation in a Swedish Population

Autor:	Dragana Škiljić, Anders Bergström, Tobias Busch, Thiemo Rudolph, Madeleine Zetterberg
Rok vydání:	2020
Předmět:	Intraocular pressure medicine.medical_specialty genetic structures Open angle glaucoma business.industry medicine.medical_treatment Glaucoma Stent Retrospective cohort study Phacoemulsification medicine.disease eye diseases Ophthalmology Cohort medicine sense organs Adverse effect business
Zdroj:	Clinical Ophthalmology. 14:3719-3733
ISSN:	1177-5483
DOI:	10.2147/opth.s267010
Popis:	Purpose Evaluation of 1-year-outcome of XEN 45 gel stent surgery in a Swedish cohort with regard to clinical success, complications, and learning curve. Patients and methods This was a retrospective study of glaucoma patients undergoing glaucoma XEN-stent surgery alone or combined with phacoemulsification between December 2015 and May 2017. Intraocular pressure (IOP), number of medical agents, and adverse events were assessed. Clinical success rate was defined as achieving individual target pressure with/without medication. Results A total of 113 eyes were included in the final statistics. Mean age was 70.8±11.8 years. Primary open angle glaucoma (POAG) accounted for 46.9% and exfoliative glaucoma (PEXG) for 40.7%. Mean preoperative IOP was 23.8±6.2 mmHg and mean number of agents 3.4. After 1 year, mean IOP was reduced to 16.1±4.7 mmHg and medication to 1.34 substances on average. Failure rate at 1-year follow-up was 34% with no significant difference between POAG and PEXG. There was a trend of higher success rate for combined cases (P=0.116). Stents with malpositioned or curved appearance had significantly worse outcome. The failure rate of the most productive surgeon dropped from 33% to 10% from the first implantations. Temporary hypotony (19.5%) and choroidal detachment (9.7%) were the most common complications. Blockage of the inner stent lumen was common (8.8%), with a high proportion of failure. Conclusion XEN-stent surgery is a surgical option in uncontrolled glaucoma in both POAG and PEXG. A XEN-stent can reduce both IOP and the number of antiglaucoma medications needed. The learning curve is significant and stent positioning is crucial for optimal results. Combined XEN-cataract surgery is not inferior to stand-alone procedures. The long-time effectiveness is still to be proven.
Databáze:	OpenAIRE
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