B-cell lymphoma with Mott cell differentiation in a cat
| Autor: | Hiroki Sakai, Takashi Mori, Naoko Matsui, Akihiro Hirata, Tomomi Kanehara, Mami Murakami, Tokuma Yanai, Kohji Maruo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty General Veterinary 040301 veterinary sciences Cytoplasmic inclusion Russell bodies 04 agricultural and veterinary sciences Anatomy Biology medicine.disease Lymphoma 0403 veterinary science 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Immunophenotyping Cervical lymph nodes 030220 oncology & carcinogenesis Tonsil medicine Lymph B-cell lymphoma |
| Zdroj: | Veterinary Clinical Pathology. 45:356-360 |
| ISSN: | 0275-6382 |
| Popis: | A 12-year-old, male castrated Domestic Shorthair cat was presented to Animal Medical Center of Gifu Univeristy with anorexia and vomiting. Physical examination revealed an enlarged left tonsil and right mandibular lymph node (approximately 2–3× the normal size), and a submucosal mass on the right side of the epiglottis (1.5 × 2.0 cm). On computed tomography images, an enlarged left tonsil, and enlarged right mandibular, right pharyngeal, and left and right cervical lymph nodes were observed. Cytologic examination of smears of tonsil and lymph nodes revealed numerous medium- to large-sized neoplastic lymphoid cells, approximately half of which contained one or several light-blue homogenous globoid cytoplasmic inclusions (5–10 μm), which stained magenta with periodic acid–Schiff (PAS) stain. Histopathologic examination of the left tonsil revealed diffuse proliferation of medium- to large-sized neoplastic lymphoid cells effacing the original lymphoid architecture. Half of the cells contained one or several eosinophilic globoid cytoplasmic inclusions, which stained magenta with PAS and showed positive immunohistochemical reactions for immunoglobulin M (IgM) and λ light chain. Neoplastic lymphoid cells were also CD20+, Pax5+, and MUM1+, and CD3−. Thus, the neoplastic lymphoid cells expressed a B-cell immunophenotype, and the globoid cytoplasmic inclusions represented an aberrant IgM λ light chain accumulation, similar to Russell bodies. B-cell lymphoma with Mott cell differentiation was diagnosed based on cytologic, histopathologic, and immunohistochemical features. This is the first report of B-cell lymphoma with Mott cell differentiation in a cat. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text