In vitro efficacies and durabilities of antibiotic/vitamin C coated hemodialysis catheters
| Autor: | Maria Refaat Boushra, Hassan Mohammed Mohi El-Din, Reham Ali Ibrahem, Gamal Fadl Mahmoud Gad |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty biology business.industry medicine.medical_treatment 030106 microbiology Hemodialysis Catheter Plant Science Ascorbic acid biology.organism_classification Antimicrobial Microbiology 03 medical and health sciences Catheter Infectious Diseases Levofloxacin Staphylococcus epidermidis Medicine Gentamicin business Intensive care medicine Central venous catheter medicine.drug |
| Zdroj: | African Journal of Microbiology Research. 11:1043-1050 |
| ISSN: | 1996-0808 |
| DOI: | 10.5897/ajmr2017.8590 |
| Popis: | Catheter associated bloodstream infections, exit-site infections, and tunnel infections are common complications related to hemodialysis central venous catheter use. Effective antimicrobial coating of catheters that can inhibit device colonization has the potential of preventing clinical infection. The study investigated in vitro the antimicrobial efficacies of hemodialysis catheters impregnated with an antibiofilm agent (ascorbic acid) (vitamin C) and a broad-spectrum antibiotics (Gentamicin and levofloxacin) against five clinical strains recently isolated from patients undergoing hemodialysis catheter removal. Impregnated catheters were also evaluated for their anti-adherence activities and durabilities. Levofloxacin/ascorbic acid (LEV/AS) catheters produced the most active and durable antimicrobial effect against both Gram-positive and Gram-negative isolates and significantly reduced adherence (P |
| Databáze: | OpenAIRE |
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