Electromyographic tendon reflex recording: An accurate and comfortable method for diagnosis of charcot-marie-tooth disease type 1a
| Autor: | Antonio G. García, José Berciano, Francisco M. Antolín, Silvia Álvarez-Paradelo, Ana L. Pelayo-Negro |
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| Rok vydání: | 2015 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities medicine.medical_specialty Adult patients Physiology business.industry Motor nerve conduction velocity Charcot-Marie-Tooth Disease Type 1A Biceps Tendon reflex Surgery Cellular and Molecular Neuroscience Electrophysiology medicine.anatomical_structure Muscle nerve Physiology (medical) Anesthesia Medicine Neurology (clinical) business |
| Zdroj: | Muscle & Nerve. 52:39-44 |
| ISSN: | 0148-639X |
| Popis: | Introduction: We analyzed the utility of tendon reflex (T-reflex) testing in Charcot-Marie-Tooth disease type 1A (CMT1A). Methods: A total of 82 subjects from 27 unrelated CMT1A pedigrees were evaluated prospectively. The series also comprised 28 adult healthy controls. Electrophysiology included evaluation of biceps T-reflex and soleus T-reflex. Results: Seventy-one individuals (62 adults and 9 children) had clinical and electrophysiological features of CMT1A. The remaining 11 (8 adults and 3 children) were unaffected. On electrophysiological testing, the biceps T-reflex was elicited in 58 of 62 (93%) adult CMT1A patients and in all 9 affected children. Latencies of the biceps T-reflex were always markedly prolonged, and a cut-off limit of 16.25 ms clearly separated adult patients and controls or unaffected kin adult individuals. In affected children, the soleus T-reflex latency was also prolonged when compared with age and height normative data. Conclusion: T-reflex testing is an accurate diagnostic technique for CMT1A patients. Muscle Nerve 52: 39–44, 2015 |
| Databáze: | OpenAIRE |
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