Synthesis and Preclinical Evaluation of an 18F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT-2

Autor:	Xiaoai Wu, Nabeel Nabulsi, Daniel Holden, David Labaree, Marcel Lindemann, Takuya Toyonaga, Jim Ropchan, Songye Li, Shu-fei Lin, Yiyun Huang, Evan Baum, Richard Pracitto, Wenjie Zhang, Sjoerd J. Finnema, Zhengxin Cai, Anupama Shirali, Richard E. Carson
Rok vydání:	2020
Předmět:	chemistry.chemical_classification 0303 health sciences Non human primate Physiology Chemistry Cognitive Neuroscience Vesicle Cell Biology General Medicine Pet imaging Biochemistry Synaptic vesicle Cell biology 03 medical and health sciences 0302 clinical medicine Transmembrane glycoprotein Glycoprotein 030217 neurology & neurosurgery Preclinical imaging 030304 developmental biology SV2A
Zdroj:	ACS Chemical Neuroscience. 11:592-603
ISSN:	1948-7193
DOI:	10.1021/acschemneuro.9b00618
Popis:	Synaptic vesicle glycoprotein 2A (SV2A) is a 12-pass transmembrane glycoprotein ubiquitously expressed in presynaptic vesicles. In vivo imaging of SV2A using PET has potential applications in the d...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0fdaa22f516164376fbe2797aeed6ea8 https://doi.org/10.1021/acschemneuro.9b00618 Zobrazit plný text záznamu