Surface immobilization of biphasic calcium phosphate nanoparticles on 3D printed poly(caprolactone) scaffolds enhances osteogenesis and bone tissue regeneration
| Autor: | Hak Jun Kim, Kyeongsoon Park, Hae Ryong Song, Daniel I. Jeon, Sungeun Kim, Kyu Sik Shim, Young Pil Yun |
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| Rok vydání: | 2017 |
| Předmět: |
General Chemical Engineering
Nanoparticle macromolecular substances 02 engineering and technology 010402 general chemistry Bone tissue 01 natural sciences chemistry.chemical_compound In vivo medicine Osteopontin biology Regeneration (biology) technology industry and agriculture equipment and supplies musculoskeletal system 021001 nanoscience & nanotechnology In vitro 0104 chemical sciences medicine.anatomical_structure chemistry biology.protein Osteocalcin 0210 nano-technology Caprolactone Biomedical engineering |
| Zdroj: | Journal of Industrial and Engineering Chemistry. 55:101-109 |
| ISSN: | 1226-086X |
| Popis: | We fabricated biphasic calcium phosphate nanoparticles (BCP NPs)-immobilized on the surface of 3D printed PCL (BCP-IM-PCL) scaffolds, and evaluated in vitro osteogenesis and in vivo new bone formation in rat tibial defect model. In vitro and in vivo studies showed that BCP-IM-PCL significantly enhanced osteogenic markers ( i.e. , ALP activity, calcium deposition, and the expression of osteocalcin and osteopontin) and markedly increased new bone formation and mineralized bone tissues in tibial defect area, compared to unmodified PCL and BCP-mixed PCL scaffolds. This study demonstrated that BCP NPs-immobilized on the surface of PCL scaffolds are promising templates for bone tissue regeneration. |
| Databáze: | OpenAIRE |
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