Cu(OAc)2-Promoted Oxidative Cross-Dehydrogenative Coupling Reaction of α-Acylmethyl Malonates with Indole Derivatives to Access 3-Functionalized Indoles and Polycyclic Indoles

Autor:	Hai-Tao Yang, Hong-Rong Guan, Li-Jin Zhou, Kun Wang, Chun-Bao Miao, An-Qi Zheng
Rok vydání:	2020
Předmět:	Indole test Nucleophile 010405 organic chemistry Chemistry Organic Chemistry Regioselectivity Oxidative phosphorylation 010402 general chemistry 01 natural sciences Medicinal chemistry Coupling reaction 0104 chemical sciences Catalysis
Zdroj:	The Journal of Organic Chemistry. 85:7925-7938
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.0c00624
Popis:	A Cu(OAc)2-promoted oxidative cross-dehydrogenative coupling reaction of α-acylmethyl malonates with indole derivatives was developed. In the case of indoles, the regioselective coupling products were formed through a sequential dehydrogenation-addition-dehydrogenation process. When a second nucleophilic center was located in the 2-position of indoles, further successive nucleophilic cyclization occurred to give polycyclic indole derivatives. The Cu(OAc)2 was proved to act as not only an oxidant but also a catalyst.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0fbc83d1f3758175cda310a631d05510 https://doi.org/10.1021/acs.joc.0c00624 Zobrazit plný text záznamu