Fatty acid synthase expression is increased in neoplastic lesions of the oral tongue
| Autor: | William E. Grizzle, Russell B. Myers, Matthew S. Mayo, Glenn E. Peters, Samuel E. Beenken, G. Dean Roye, Helen Krontiras |
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| Rok vydání: | 1999 |
| Předmět: |
Mild Dysplasia
Pathology medicine.medical_specialty biology business.industry medicine.disease Epithelium stomatognathic diseases chemistry.chemical_compound Fatty acid synthase medicine.anatomical_structure Otorhinolaryngology chemistry Epidermoid carcinoma Tongue Dysplasia medicine biology.protein Immunohistochemistry business Fatty acid synthesis |
| Zdroj: | Head & Neck. 21:325-329 |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/(sici)1097-0347(199907)21:4<325::aid-hed6>3.0.co;2-p |
| Popis: | Background Fatty acid synthase (FASE) is required for fatty acid synthesis. Elevated levels of FASE have been observed in a variety of malignancies. Methods We examined the expression of FASE in 56 primary squamous cell carcinomas (SCC) of the tongue using immunohistochemistry (IHC) with a monoclonal antibody to FASE. Results Immunoreactivity was low in histologically normal epithelium (0.42 ± .07, n = 43), moderate in mildly dysplastic epithelium (1.41 ± 11, n = 40), and strong in SCC of the tongue (1.64 ± 10, n = 50). Both mild dysplasia and SCC stained more strongly than histologically normal epithelium (p |
| Databáze: | OpenAIRE |
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