| Autor: |
Nina Lagerqvist, Kimia Maleki, Jenny Verner-Carlsson, Mikaela Olausson, Joakim Dillner, Julia Wigren, Tor Monsen, Mattias Forsell, Jenny Eriksson, Gordana Bogdanovic, Sandra Muschiol, Joel Ljunggren, Johanna Repo, Torbjörn Kjerstadius, Shaman Muradrasoli, Mia Brytting, Åsa Szekely Björndal, Tomas Åkerlund, Charlotta Nilsson, Jonas Klingström |
| Rok vydání: |
2021 |
| DOI: |
10.21203/rs.3.rs-148363/v1 |
| Popis: |
We evaluated the performance of eleven SARS-CoV-2 antibody tests using a reference set of heat-inactivated samples from 278 unexposed persons and 258 COVID-19 patients, some of whom contributed serial samples. The reference set included samples with a variation in SARS-CoV-2 IgG antibody titers, as determined by an in-house immunofluorescence assay (IFA). The five evaluated rapid diagnostic tests had an IgG-based specificity of 99.0% and a sensitivity that ranged from 56.3–81.6% and decreased with low IFA titers. The specificity was > 99% for five out of six platform-based tests, and when assessed using samples collected ≥ 22 days after symptom onset, two assays had a sensitivity of > 96%. These two assays also detected samples with low IFA titers more frequently than the other assays. In conclusion, the evaluated antibody tests showed a heterogeneity in their performances and only a few tests performed well with samples having low IFA IgG titers, an important aspect for diagnostics and epidemiological investigations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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