Review Article: 'Mesenchymal Tumor' or 'Decidual-Like Reaction'?
| Autor: | Eberhard Karbe |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Leiomyosarcoma
medicine.medical_specialty Pathology 040301 veterinary sciences Biology Toxicology 030226 pharmacology & pharmacy Pathology and Forensic Medicine 0403 veterinary science Lesion 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Molecular Biology Anaplasia Decidualization 04 agricultural and veterinary sciences Cell Biology medicine.disease Decidual reaction Endocrinology Smooth Muscle Tumor Metrial Gland medicine.symptom Epithelioid cell |
| Zdroj: | Toxicologic Pathology. 27:354-362 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1177/019262339902700312 |
| Popis: | For more than 40 yr, an unusual urinary bladder lesion has been known to occur in certain strains of mice, but no consensus has been obtained regarding its etiology, pathogenesis, biology, or classification. The lesion was first assumed to be epithelial and non-neoplastic, then it was called a smooth muscle cell tumor or leiomyosarcoma because of ultrastructural characteristics for smooth muscle cells. Later, the nonspecific term "mesenchymal tumor" was introduced due to histomorphologic differences from all smooth muscle tumors known. Recently, a proposal was made to name it "decidual-like reaction" because of the histomorphologic similarity to the rare spontaneous decidual reaction in the uterus of aging mice. Both lesions are characterized by spindle and large pleomorphic epithelioid cells with large bizarre nuclei; these characteristics mimic anaplasia of malignant tumors and led pathologists to assume a neoplastic nature. The decidual hypothesis is supported by the regular presence of nuclear progesterone receptors, the occasional occurrence of eosinophilic cytoplasmic granules, the rare finding of cells morphologically resembling granulated metrial gland cells (all also observed in the uterine decidual reaction), and the reproducibility through long-term feeding of combinations of estrogens and progestogens. It appears that the new decidual hypothesis can explain many detailed facets of the lesion, with the exception of the reported smooth muscle cell characteristics. The controversy of "mesenchymal tumor versus decidual-like reaction" should be resolved soon, not only as a scientific issue, but also because of consequences for risk assessment. |
| Databáze: | OpenAIRE |
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